Principal Investigator: Majid Ghayour-Mobarhan

Metabolic syndrome Research Center, Mashhad, University of Medical Science, Mashhad, Iran.. - University Pardis, Medical Sciences/ 917791-8564, , 99199-91766; Tel: +985138002288, Fax: +985138002287. - Ghayourm@mums.ac.ir

Part Cohort

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A Cohort Study of Stroke and Heart Atherosclerotic Disorders in Mashhad


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A Cohort Study of Stroke and Heart Atherosclerotic Disorders in Mashhad


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A Cohort Study of Stroke and Heart Atherosclerotic Disorders in Mashhad


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A Cohort Study of Stroke and Heart Atherosclerotic Disorders in Mashhad


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 Approval date: Phase I: 2007 Phase II: 2016.09.11

 Starting date: Start of Phase II: 2017.10.23

 Goals: -To assess the influence of environmental, nutritional, psychosocial and genetically risk factors on the prevalence of cardiovascular events. - To carry out health plans to reduce the cost of treatment-induced disease, early diagnosis of disease, and therapeutic prevention. -The diagnosis and treatment of cardiovascular risk factors among the first-degree relatives of these patients is the most important factor in reducing the incidence as well as the mortality rate of heart attacks. - To examine the effect of fasting on cardiovascular diseases. -The development of diagnostic and predictive methods in susceptible individuals and the use of appropriate strategies such as lifestyle and dietary changes, exercise, and periodic laboratory studies are important goals of this study to prevent CVD events.

 Study population: Mashhad urban population.

 Sampling method and sample size: In the first phase of MASHAD study, 9704 people from the urban population of Mashhad were enrolled using a stratified-cluster method. The classes of health centers were No. 1, 2 and 3 of Mashhad, and the clusters were the areas covered by these centers.

 Data Collection: All necessary data about participant’s demographics (e.g., age, education and marital status), lifestyle (e.g., cigarette smoking and physical activity level), diet, medical history were collected through standard questionnaires at baseline by health care professionals and a nurse interview. Collecting blood, hair, nail and urine samples. Measurement of anthropometric parameters including weight, height, BMI, waist circumference, hip circumference and waist/hip ratio as well as systolic and diastolic blood pressures.

Follow up Methods: We collected all necessary data during three follow–up periods. The first and second follow-up started in 2010 and 2013 that some participants claimed to have a CVD event. Finally cardiologist confirmed subjects with cardiovascular events at the third follow-up from April 2015 to May 2016. Ten-years follow up of participants in second phase of MASHAD study was started in 2017 and it is going on.

 Main Exposures: Smoking and drug, Alcoholic, Air and environmental pollution, Dietary pattern

 Outcomes: Main outcomes: stork and cardiovascular diseases rates in the population studied. Other outcomes as confounding factors: All common risk factors (traditional risk factors) for cardiovascular disease

Last Publications

Association of dietary patterns and risk of cardiovascular disease events in the MASHAD cohort study


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