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 Approval date: 1394

 Starting date: 1395

 Goals: 1. To determine the incidence and prevalence of the risk factors and non-communicable diseases in adults, particularly cardiovascular disorders, chronic renal and liver disorders, diabetes, cancers. 2. To design intervention studies to determine the effect size of the interventions in order to reduce burden of NCDs as primary and secondary prevention plans.

 Study population: Enrollment of All adults aged 35-70 years living in Kong City.

 Sampling method and sample size: All the adults aged 35-70 years, approximately 5000 males and females who are the resident of King City would be participated in the study.

 Data Collection: The recognized subjects were invited and explained the circumstances by cohort stuff one week before. Using computerized structured questionnaire and face-to-face interview, data collection including demographic and socio-economic variables, FFQ, personal, family and past medical history, anthropometric measurements, medical physical exam as well as biological sampling including blood, urine, nails and hair are carried out. The specimens are stored in -20°c , -70°c until use.

 Follow up Methods: Annual follow-up by phone is performed for mild to moderate disease occurrences, which are managed in clinics and OPD. In case of unavailability to the enrolled subjects or severe diseases occurred and/or death, cohort staff will follow the case at the located residence to inquire the status and collect the needful data.

 Main Exposures: Demographic variables, personal and family records, socio-economic and job risk factors, environmental factors, life style, environmental and water source pollutions, anthropometric risk factors resulting morbidity and/or mortality from NCDs as well as genetic investigations.

 Outcomes: Mild to severe NCDs, CVDincidence and prevalence, metabolic disorders,common adultand senile disorders, chronic renal and hepatic and respiratory disorders, musculoskeletal and psychological diseases,trauma and traffic accidents

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