Principal Investigator: Dr. Nader Saki

- Associate Professor of Otolaryngology, hearing research center,Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran - Cohort study bulding , Hoveizeh city, Tel: 06136788141 - ahvaz.ent@gmail.com,saki-n@ajums.ac.ir , hoveizeh.cs@ajums.ac.ir

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Approval date: 14/03/2016 (2016 March 14)

 Starting date: 12/05/2016 (2016 May 12)

 Goals: To determine prevalence and incidence rates of NCDs and trends of risk factors and their outcomes in Hoveizeh district

 Study population: Adult people aged between 35-70 years.

 Sampling method and sample size: All of 10000 eligible adults between 35-70 years old entered to the study by census method.

 Data Collection: The exposures were measured by relevant standard tools and questionnaires. Data on general health, personal and working life history, medical examination, the frequency, prevalence, and history of NCDs, exposure to and risk factors for NCDs, lifestyle, physical activity, and nutrition (Food Frequency Questionnaire (FFQ)) were collected by electronic questionnaires. Blood, urine, hair, and nail specimens were gathered and stored in the HCS Biobank. For eye cohort eye exam, refractory error, funduscopic exam and retinal imaging, for ear cohort ear exam and audiometry is done. All steps of data collection and examinations were directly monitored by the quality control team.

 Follow up Methods: In the follow up phase, subjects under study are followed in both active ways phone interview and passive ways by reports obtained through self-reports or disease registries centers, annually. To evaluate changes of risk and protective factors in second, third and fourth screening (fifth, tenth and fifteenth years later), measurement of anthropometric indices and blood, urine, hair and nail sampling will be done. Also lifestyle and nutrition questionnaire will be filled again. Death or unwillingness of individual to being under research will be consider as the end of study

 Main Exposures: Main exposures for each participant were collected and recorded online through three general, nutritional and medical questionnaires and generally include the following: Demographic information (age, gender, socioeconomic status and job history, level of education),Life style, animal contact history, history of used fuel type, exposure to pesticides, physical activity and sleep status, frequency of feed intake and food habits, supplements consumption and amount of water used, History of diseases, reproductive history, evaluation of personal habits (alcohol and cigarettes), physical and oral examinations, measurements of anthropometric indices and blood pressure, pulse, biochemical and hematological measerments.

 Outcomes: death (cause-specific death) and major non-communicable disease including cardiovascular risk factors and heart disease (such as hypertensive disease, myocardial infarction and ischemic heart diseases), cerebrovascular accidents (CVA, Stroke), cancers, diabetes mellitus, asthma , chronic obstructive pulmonary disease, pulmonary emphysema, kidney diseases that lead to dialysis, liver and gastrointestinal diseases like liver cirrhosis and trend of risk factors.

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