Principal Investigator: Dr Ashraf Aminorroaya & Dr Massoud Amini

Isfahan Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences . Isfahan Endocrine & Metabolism Research Center, Sedigheh Tahereh Medical Research Complex, Khorram Street, Isfahan, Iran. aminorroaya@med.mui.ac.ir & m_amini@med.mui.ac.ir

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Isfahan Thyroid Cohort Study


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Isfahan Thyroid Cohort Study


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Approval date:

2004

 

Starting date:

2006

 

Goals:

- To determine the prevalence and incidence of overt and subclinical hypothyroidism, overt and subclinical hyperthyroidism, thyroid nodule, goiter and thyroid autoimmunity and iodine status by sex, age, parity, menopause, smoking habbit and … in Isfahan city. - To determine the value and power of thyroid autoantibodies, age, BMI, FPG, positive family history of thyroid diseases, history of smoking, abortion and age at menopause for prediction of occurrence of above-mentioned thyroid disorders. - To determine the reference range for T3, T4, TSH and T3RU by sex and age groups

 

 

Study population:

Adult population of Isfahan City (age>20 years)

 

Sampling method and sample size:

Cluster sampling 3000 people

 

Data Collection:

- Enrolment of adult population of Isfahan city by cluster sampling of families - Data collection forms about age, sex, history of thyroid disease, drug history, parity, abortions, age at menopause, smoking, - Clinical and ultrasonographic examination for goiter, thyroid nodules - Measurement of TSH, T4, T3, T3RU or TSH if indicated FT4, thyroid autoantibodies including, TPOAb

 

Follow up Methods:

-First phase: 2006 -Second phase: 2011 -Third phase: 1398 -5 to 10- year interval follow up forever by recalls and repeating the protocol for euthyroid people

 

Main Exposures:

Demographic, anthropometric measurements, age of menopause, number of parity and abortions, past history of thyroid disorders and smoking, use of medications, especially drugs that interfere with thyroid function, and the past medical history

 

Outcomes:

Overt and subclinical hypothyroidism, overt and subclinical hyperthyroidism, thyroid nodule, goiter and thyroid autoimmuity, iodine deficiency or excess

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