Principal Investigator: 1)Ahmad Ali Enayati, 2) Mahmood Moosazadeh

- 1) Professor of Medical Entomology, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran, 2) Ph.D. in Epidemiology, Assistant professor, Health Sciences Research center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran - 1) Mazandaran University of Medical Sciences, 2) Mazandaran University of Medical Sciences - 1) ahmadali_enayati@yahoo.com, 2) mmoosazadeh1351@gmail.com - 1)+98-9111522209, 2)+98-9113555367

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 Approval date: 24 September 2014

 Starting date: 1 June 2015

 Goals: Identifying the risk factors related to non-communicable diseases for implementation of appropriate interventions to prevent the diseases

 Study population: people aged 35- 70

 Sampling method and sample size: All resident of selected areas will be enrolled. Sample size is equal 10000.

 Data Collection: Data will be collected using electronic questionnaire, specimens consisting Blood, urine, nail and hair samples will be collected.

 Follow up Methods: Tabari cohort follow-up includes annual and periodic follow-up (re-measurement). All participants were contacted every year in order to ascertain major NCDs. The periodic follow-up will be conducted every 5 year .Among all participants, 20% will be selected randomly. They will be re-interviewed and all biological samples will be collected.

 Main Exposures: All risk factors related to chronic diseases including genetic factors, life style, socioeconomic status and environment contamination

 Outcomes: There are three kind of outcomes of interest, including: 1. Death (confirmed cause of death), 2. Major NCDs including malignancies, cardiovascular diseases(myocardial infarction and other ischemic heart diseases, hypertension and heart failure), stroke, cerebrovascular accident, diabetes mellitus, pulmonary disease(Asthma, pneumoconiosis, COPD, chronic bronchitis and pulmonary emphysema), chronic renal failure leading to dialysis, hepatic fibrosis and cirrhosis, alzheimer and parkinson and 3.trends in risk factors or protective factors including anthropometric, physiologic, nutritional, life style, environmental and occupational factors.

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