Principal Investigator: Fereidoun Azizi

Professor of Internal Medicine and Endocrinology- Shahid Beheshti University of Medical Sciences- Director, Research Institute for Endocrine Sciences

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Tehran Lipid and Glucose Study (TLGS)


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Tehran Lipid and Glucose Study (TLGS)


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Tehran Lipid and Glucose Study (TLGS)


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Tehran Lipid and Glucose Study (TLGS)


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Approval date:

1998

Starting date:

1999

Goals:

To study the incidence of non-communicable diseases and the association between different exposures and outcomes.

Study population:
The families residing in distinct no. 13 of Tehran including all family members aged three years and above.

Sampling method and sample size:
Random two-stage cluster sampling; Recruiting 15000 individuals in the first and 3500 in the second phase.

Data Collection:
Interview, self-administered questionnaire, physical exam, ECG, biochemical measurements, storing serum and DNA sample.

Follow up Methods:

- Active fallow-up every 3 years to repeat all measurements. Up to now, 6 examinations have been conducted. - Active follow up annually for hospitalized events and death. Up to know, 18 years of follow-up have been completed.

Main Exposures:

Demographic, behavioral (e.g. nutrition, physical activity and smoking), medical history, family history, biological (e.g. anthropometric, blood pressure, pulse rate), biochemical (e.g. serum levels of glucose, lipid profile and kidney, liver and thyroid function tests) and genetic factors.

Outcomes:

NCDs events especially cardiovascular diseases, diabetes and other metabolic disorders and cancer. Up to Mar 2016 for any death and hospitalization and up to Mar 2017 for all measurements (Phase 6 of the TLGS) including self-reported physician diagnosis, drug history, and diagnoses based on physical exams and lab measurements, e.g. hypertension and diabetes.

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Last Publications

Evaluating the interaction of common FTO genetic variants, added sugar, and trans-fatty acid intakes in altering obesity phenotypes


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