Principal Investigator: Dr. Iraj Mohebbi

- Social Determinants of Health Research Center, Occupational Medicine Center, Urmia University of Medical Sciences, Urmia, Iran. - Urmia University of Medical Sciences, Resalat Street, Urmia, Iran. Tel: +98-32231930. Fax: 04432240642. - irajmohebbi@umsu.ac.ir

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 Approval date: 13/04/2016

 Starting date: 09/02/2017

 Goals: 1. Determination of the incidence rate of chronic non-communicable disease in the sample population of adults aged 35-70 years within the study area (in 5 km distance from Urmia Lake) 2. Identification of risk factors and their relationship with the incidence of non-communicable disease in this area 3. Determination of the incidence of outcomes in association with the occurrence of this type of diseases in the study area population

 Study population: 5000 adult subjects with 35-70 years of age

 Sampling method and sample size: One sample population (35- to 70-years of age) will be recruited via census sampling method and followed up for 15 years. Taking into consideration the 10-percent predicted annual drop out, finally 5,500 subjects will recruited in the study.

 Data Collection: In accordance with the Persian cohort study protocol, data on the personal, social, economic, anthropometric, physical activity status, nutrition, nutritional habits, diseases, drug use history, and clinical examinations, etc., were obtained through the validated questionnaires. Gathered data was entered online in the cohort website database. In addition, blood and urine samples were taken from each subject. The results of laboratory biochemical and blood tests were recorded in the laboratory specific software and then transferred to the cohort data base system. Also nail and hair samples were collected from individuals. Collected samples are deposited in the BioBank for long-term storage.

 Follow up Methods: Individuals will be followed up annually for a period of fifteen years. Follow up can be performed actively and passively. Phone call and face-to-face contact are two active follow up forms, while self-report and reports from disease registry centers are passive follow up formats. Also, in the fifth, tenth and fifteenth years, re-sampling will be done and data related to anthropometric measurements, lifestyle and food consumption will be gathered. Total follow up periodwill be 15 years.

 Main Exposures: Demographic characteristics, Socioeconomic status and social factors, Lifestyle, Occupational history, Physical activity and physical disability status, Fuel use type and location, Sleep Status, Mobile phone use status, Use of pesticides, Past and present medical status and history, History of fertility (for women), Oral health status, Personal habits (drugs and alcohol use), Nutrition and dietary habits, water use and nutritional supplements use, Level of blood pressure, Communicable and non-communicable diseases history, Medication used history

 Outcomes: Death (cause of death), major non-communicable diseases and changes in risk factors or disease-protecting factors

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