Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Principal Investigator:Hamid Najafipour
-Professor of Cardiovascular Physiology
-Kerman University of Medical Sciences
-Director, Physiology Research Center
Approval date
October 2009
Starting date
10 Nov 2009
Goals
Assesment of prevalence and incidense of 9 CAD risk factors and mortality rates among 15 to 80 years old people living in Kerman
Study population
10,000 people aged between 15 to 80 from households that reside in Kerman and live in the city for at least 1 year ago
Sampling method and sample size
One-stage cluster sampling household survey based on city postal codes- Recalling 5900 people that participated in Phase I and inviting for new cases up to sample size of 10,000
Data Collection
Using a structured questionnaire including demographic information (education, job ,,,), cigarette and opium smoking, physical activity, nutrition habits, anxiety, depression. blood pressure measurement and dose of medicines in use and medical history, Oral and dental hygiene, assessed by general physician and dental doctors. Also, determining FBS, Chol, HDL, LDL and TG, and HbA1c for diabetic patients. Storing blood serum/DNA in -80c.
Follow up Methods
One-year active tracking of subjects by telephone contact to record the incident of cardiovascular events or mortality.
5-year active tracking of subjects participated in phases 1 and 2 by telephone contact and inviting them to repeat the measurements.
Main Exposures
Nine CAD risk factors of: 1-Diabetes, 2-Hypertension, 3- Hyperlipidemia, 4-Cigarette smoking and opium use, 5- Overweight and obesity, 6- Level of physical activity,7- Depression and anxiety, 8-Nutrition status, 9- Oral and dental hygiene
Outcomes
1-Prevalence and 5-year incidence of the above 9 risk factors, plus incidence of MI
2-Determination of reasons for hospitalization
3-All cause mortality rate
4-Specific cardiovascular mortality rate
Introduction-KERCADRS
The KERman Coronary Artery Disease Risk Factors (KERCADRS) is a relatively large population-based cohort study performed on the population aged 15 to 75 years living in Kerman by Physiology Research Center of Kerman University of Medical Sciences(KPRC).
The first phase of this study was performed on 5900 individuals that began in September 2009 and ended in December 2011. The aim of the cohort was to evaluate the prevalence, incidence and trend of 9 risk factors for coronary artery disease including: hypertension, diabetes, overweight and obesity, hyperlipidemia, sedentary lifestyle, mental health, smoking and addiction, nutrition status, and oral health status. From the results of the first phase of the study, 44 articles were published. In the second phase of the study, which started 5 years after the first phase we the recalled the participants of first phase and invitated new participants to reach a sample size of 10,000, started in October 2014 and ended in September 2018.
Outcomes studied in this phase include: instantaneous prevalence and 5-year incidence rate of 9 risk factors mentioned, the incidence of heart attack and stroke, the causes of hospitalization, the raw and specific death rate associated with cardiovascular diseases. A large number of clinical faculty members in various specialties such as cardiology, endocrinology and metabolism, psychiatry, dentistry, gastrointestinal tract, kidneys and internal organs along with faculty members of Physiology and Biochemistry collaborated with KPRC. The third phase of this project has started in December 2019 with the recall of 10,000 participants of the second phase.
Phase1/Phase2/Phase3 Questionaires
News
از یکشنبه 16 شهریور 1399، فاز سوم کوهورت قلبی عروقی کرمان که به دليل شیوع بیماری کرونا از اسفندماه 1398 تعطیل شده بود؛ مجددا با رعایت پروتکلهای بهداشتی آغاز بکار کرد.
Publications
Published papers from second round of cohort of:
“Kerman Coronary Artery Disease Risk Factors Study (KERCADRS)”
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Published papers from first round of cohort of:
“Kerman Coronary Artery Disease Risk Factors Study (KERCADRS)”
- Najafipour H, Moazenzadeh M, Afshari M, Nasri HR, Khaksari M, Forood A, Sheikzadeh K, Mirzazadeh A. Prevalence of Low Physical Activity and its relationship with Other Cardiovascular Risk Factors: a Community-based Study (KERCADRS). Asian ARYA Atheroscler 2016;12(5):212-219.
- Najafipour H, Askaripour M, Hosseinzadeh A, Sadeghi Z. The Prevalence of Coronary Artery Diseases Risk Factors in Four Regions of Kerman City. JKUMS 2016;23(4):406-420. [Article in Persian]
- Yousefzadeh G, Gozashti MH, Najafipour H, GholamhosseinianNajar A, Bahramnejad A, Shokouhi M. Common autoimmune biomarkers, thyroid hormonal abnormalities, and beta cells dysfunction in patients with latent autoimmune diabetes in adults with type II diabetes mellitus. Diabetes&Metabolic Syndrome: Clinical Research&Reviews 10S (2016);S52–S55.
- Safavi F, Yousefzadeh G, Shokoohi M, Safavi S, Najafipour H, ShadkamFarokhi M.Prevalence of Metabolic Syndrome in Patients with Periodontal Disease. Journal of Kerman University of Medical Sciences 2015;22(3):229-239.[in Persian].
- Gozashti MH, Shafiei M, EsmaeilianS, Najafipour H, MashroutehM. The prevalence of latent autoimmune diabetes in adults and its correlates in patients with type 2 diabetes in Kerman, Iran[2011]. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2015 Apr-Jun;9(2):104-7.
- Najafipour H, Nasri HR, Afshari M, Moazenzadeh M, Shokoohi M, Forood A, Koorosh E, Sadeghi B, Mirzazadeh A. Hypertension, Pre-Hypertension, Undiagnosed and Uncontrolled Hypertension and its Predictors in General Population Aged 15 to 75 Years: A Community-based Study in Southeastern Iran. International Journal of Public Health 2014;59(6):999-1009.
- Hayatbakhsh M, Zahedi MJ, Darvish-moghaddam S, Seyedmirzaie SM, Najafipour H, Haghdoust AA, Mahmoudi A.The Prevalence of Irritable Bowel Syndrome, and its Clinical Symptoms and Related Factorsamong the Adult Population of Kerman,Iran. Journal of Kerman University of Medical Sciences 2013;20(4):331-342.[in Persian]