A 10-year Isfahan cohort on cardiovascular disease as a master plan for a multi-generation non-communicable disease longitudinal study: methodology and challenges

Authors

Nizal Sarrafzadegan1,2 Razieh Hassannejad3Hamidreza Roohafza4Masoumeh Sadeghi4Mohammad Talaei1,5
Shahram Oveisgharan6,7 Marjan Mansourian3
1 Isfahan Cardiovascular Research Center, Cardiovascular Research
Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2School of Population and Public Health, Faculty of Medicine,
University of British Columbia, Vancouver, Canada
3Department of Epidemiology and Biostatistics, School of Public
Health, Isfahan University of Medical Sciences, Isfahan, Iran
4Cardiac Rehabilitation Research Center, Cardiovascular Research
Institute, Isfahan University of Medical Sciences, Isfahan, Iran
5Health Services and Systems Research, Duke-NUS Medical
School, Singapore, Singapore
6Department of Neurology, School of Medicine, Tehran University
of Medical Sciences, Tehran, Iran
7Rush Alzheimers Disease Center, Rush University Medical
Center, Chicago, Illinois, US
Journal of Human Hypertention

Abstract

A 10-year longitudinal population-based study entitled Isfahan Cohort Study (ICS) was conducted in 2001–2011 with cardiovascular disease (CVD) as the primary outcome. We considered ICS as a master plan for a multi-level non-communicable disease (NCD) study named Isfahan Cohort Study 2 (ICS2). ICS2 is a multi-generation 10-year cohort study with new goals and outcomes that have been started in 2013, recruiting a sub-sample of ICS (n = 1487) and a new recruited sample (n = 1355) aged 35 years and over, all living in urban and rural areas of two counties in central Iran. In addition, 2500 of participant’s adult children were selected randomly, as well as 1000 of their grandchildren. The aim of ICS2 is to detect the incidence of some NCDs including CVD, cancers, and diabetes and to identify the impact of their behavioral, metabolic, environmental, and genetic risk factors. In addition, studying lifestyle behaviors in three generations in a hierarchical manner of parents, their children and grandchildren in ICS2 will improve our knowledge on other determinants such as epigenetics of NCDs.

How to Cite

Nizal Sarrafzadegan ●Razieh Hassannejad●HamidrezaRoohafza●Masoumeh Sadeghi●Mohammad Talaei ●Shahram Oveisgharan ●Marjan Mansourian. A 10-year Isfahan cohort on cardiovascular disease as a master plan for a multi-generation non-communicable disease longitudinal study: methodology and challenges. November 2019Journal of Human Hypertension 33(1)
DOI:10.1038/s41371-018-0126-2.